In Pursuit of the Gene: From Darwin to DNA | 
| Author: James Schwartz
Publisher: Harvard University Press
Category: Book
List Price: $29.95
Buy New: $14.97
You Save: $14.98 (50%)
New (36) Used (10) from $12.88
Avg. Customer Rating:  2 reviews
Sales Rank: 121705
Media: Hardcover
Number Of Items: 1
Pages: 384
Shipping Weight (lbs): 1.6
Dimensions (in): 9.3 x 6.2 x 1.3
ISBN: 0674026705
Dewey Decimal Number: 576.509
EAN: 9780674026704
ASIN: 0674026705
Publication Date: April 30, 2008
Availability: Usually ships in 1-2 business days
Shipping: Expedited shipping available
Shipping: International shipping available
Condition: Brand New. 100% money back guarantee. All books shipped from Strand Bookstore, New York City, USA.
|
| Similar Items:
|
| Editorial Reviews:
Product Description
The mystery of inheritance has captivated thinkers since antiquity, and the unlocking of this mystery?the development of classical genetics?is one of humanity’s greatest achievements. This great scientific and human drama is the story told fully and for the first time in this book. Acclaimed science writer James Schwartz presents the history of genetics through the eyes of a dozen or so central players, beginning with Charles Darwin and ending with Nobel laureate Hermann J. Muller. In tracing the emerging idea of the gene, Schwartz deconstructs many often-told stories that were meant to reflect glory on the participants and finds that the “official” version of discovery often hides a far more complex and illuminating narrative. The discovery of the structure of DNA and the more recent advances in genome science represent the culmination of one hundred years of concentrated inquiry into the nature of the gene. Schwartz’s multifaceted training as a mathematician, geneticist, and writer enables him to provide a remarkably lucid account of the development of the central ideas about heredity, and at the same time bring to life the brilliant and often eccentric individuals who shaped these ideas. In the spirit of the late Stephen Jay Gould, this book offers a thoroughly engaging story about one of the oldest and most controversial fields of scientific inquiry. It offers readers the background they need to understand the latest findings in genetics and those still to come in the search for the genetic basis of complex diseases and traits. (20080517)
|
| Customer Reviews:
A Triumph of Reason over Ideology August 8, 2008
4 out of 5 found this review helpful
I liked this book a lot the first time I read it. After finishing the book, there were many details, and not a few key points, that I had not consigned to memory, so I read it again. It was so good the second time that I read it a third time. This is a great book---Schwartz writes science history as though it were a fast-paced detective story with a plethora of personal details and exciting subplots. I am reminded of Elof Axel Carlson's fine history, Mendel's Legacy: The Origins of Classical Genetics, which the reader might also find complementary to Schwartz' account.
The subtitle is slightly inaccurate. The book is really about genetics from Thomas Hunt Morgan, Hugo de Vries, and William Bateson to Hermann Muller, although there are very interesting chapters on Galton, Weldon, and Mendel. Hermann Muller is clearly the standout figure in this whole saga, and the book could have been entitled "The Age of Hermann Muller: Precursors and Contemporaries."
Despite the skill of the author, this book cannot be read by everybody. This is because the scientific concepts involved, although carefully explained by Schwartz, are complex and subtle, and most people simply do not get enough pleasure from thinking hard to render learning them worthwhile. This pains me deeply. Why can we all appreciate music, art, literature, sports, sex, humor, and cuisine, while only a minority get equal pleasure from science? It is probably this imbalance that accounts for the presence of post-modernism in academia, creationism in popular ideology, and the indomitable tendency for truth to be sacrificed on the altar of political correctness. The most heart-rending story in this book is Schwartz' account of how the anti-genetics quack Lysenko won the heart of Stalin, leading to the destruction of Soviet agriculture and the persecution of the most talented and dedicated scientific agronomists, including Muller's host in Russia, Vavilov, who died of torture and starvation in a Soviet prison (his lesser-known colleagues were simply shot). A similar anti-science/anti-technology ideology condemned many millions to starvation in Mao Tse Tung's infamous "politics in command," period in Chinese history.
The standard story is that the monk Gregor Mendel discovered the laws of genetic segregation, publishing a monograph on the subject in 1865. This monograph was widely ignored, and Mendel's laws were rediscovered in the early years of the next century. Schwartz argues that Mendel's writings were rediscovered, although more than one scientist claimed independent discovery of the laws of genetic segregation. Moreover, Mendel was not just a simple monk whose work slipped under the radar. Mendel actively promoted his work, but it was opposed by many who considered it to be at variance with the facts. Even as late as 1925, there were many prominent anti-Mendelians, and the opposition to his genetic principles was based solidly on empirical evidence. For instance, de Vries, one of the rediscoverers of Mendel's laws, later came to believe that most genetic inheritance was not Mendelian. De Vries followed the lead of the French hybridist Millardet, who found that in many plants that bred true for several generations, crosses with related species led to two highly stable hybrids, a phenomenon ostensibly incompatible with Mendelian laws. De Vries' Oenothera Lamarckiana, which he cultivated and studied over many generations, was one of these plants, and de Vries developed a complex theory of discontinuous mutation based on hybridization.
It was characteristic of virtually all biologists of the period to hold strongly to particular models of genetic inheritance, despite the fact that the evidence was deeply ambiguous and appeared incompatible with all models. Muller held an unshakable belief in the universality of Mendel's laws. Indeed, his phenomenal success stemmed from his unwavering faith, together with great observational and experimental skills. Eventually he worked out the correct model of Oenothera Lamarckiana and other "false hybrids," finding that these plants were obligate heterozygotes because both homozygotes at the relevant locus were lethal.
Muller's explanation of "false hybrids" also undermined de Vries' elaborate theory of discontinuous mutation, and left the field for Muller and others (especially Altenberg) to develop the correct theory of heritable point mutations. But, I don't want to reveal too much of the plot, which would take away some of the fun for the reader.
Genes and geniuses May 13, 2008
6 out of 6 found this review helpful
Science (like evolution) is winners' history: we live in a world of things that work, and the reason things work is that they've been successful. The history of science is fascinating because it's all about the sheer contingencies that somehow combined to give modern understanding its aura of inevitablity. Nothing's more fun than to get a glimpse of brilliant people who not only didn't know what we know, but who thought hard about things that never even occurred to us. To really understand science, to understand the ideas and not just to make use of them, you have to go deeply into the history of science and see what ideas looked like before they won (or lost). Schwartz, an amazingly good writer who does really understand science, and also understands narrative (he writes like a novelist), makes the thinking, the debates, the brilliant wrong ideas, the surprises about which ones were right, fresh and exciting. The history (based on original archival work and interviews with some of the players in the story, as well as their survivors) is fascinating on its own, but will also be valuable for anyone interested in what an exciting new idea looks like. Most exciting new ideas don't pan out; but all the winners were exciting once, and this book shows how and why.
|
|
|
